Conference Day One

Wednesday, May 22, 2024

9:00 am Check In & Morning Coffee

9:15 am Chair’s Opening Remarks

Optimizing the Selection of Polymers to Synthesize a Tailor-Made Delivery Vehicle

9:30 am Panel Discussion: The Polymer Past, Present and Future – an Evolving Selection Dilemma

Synopsis

  • Reflecting upon the journey of polymer drug delivery vehicles from historic to present day synthesizing techniques
  • Highlighting the properties of traditional polymers including PLGA, PGA, PLA and more to provide the building blocks of next-generation polymer design
  • Driving innovation in polymer synthesis whilst reducing time of development, utilizing existing research to inspire design

10:15 am Honing the Dynamic between Polymer and API to Allow for Successful Polymer Selection

Synopsis

  • Creating a polymer design process focused on API compatibility to trigger sufficient association for delivery
  • Successfully modelling API solubility with polymer to understand hydrophobic interactions in clinical models
  • Sharing experimental data which prove stability for sustained drug delivery, in varying temperature and ph conditions

10:45 am Discovering Advanced Polymeric Systems by an Automated and AI-Driven Polymer Chemistry Platform

  • Adam Gormley Associate Professor, Biomedical Engineering, Rutgers University

Synopsis

  • Automation programmed to synthesize combinatorial polymer libraries
  • Machine learning to direct the design of novel polymer excipients
  • Integrated automation and artificial intelligence towards a self-driving lab for excipient design and bioformulation

11:15 am Morning Refreshments & Speed Networking

Synopsis

A dedicated hour to chat LNPs over a coffee, put a face to a name and exchange business cards in a controlled networking set up designed to ensure you have the chance to meet everyone in the room, multiplying your LNP network by the minute! 

Comprehending the Chemical Dynamics in Motion to Form a Functional, Soluble and Stable Polymer

12:15 pm Transforming Gut Health: Harnessing Amphiphilic Block Copolymer Nanoparticles for Targeted Delivery of Bacterial Metabolites

Synopsis

  • Leveraging and fine-tuning the hydrophobic properties of short chain fatty acids for
  • effective lower gut delivery
  • Tailoring neutral and anionic hydrophillic copolymer systems for optimized targeting mechanisms
  • Creating nanoparticles in a physiologically relevant solvent system for enhanced solubility and prolonged stability

12:45 pm Benchmarking Polymer Membrane Diffusion-Based Drug Delivery Systems

Synopsis

  • Identifying key product parameters for diffusion-based delivery
  • Demonstrating proof of concept, diffusion-based systems are well controlled with low systemic and local toxicities
  • Leveraging non clinical and clinical data to expand indications and opportunities

1:15 pm Cultivating a Delivery Vehicle Showcasing Long-Term Stability to Reduce Significant Degradation

  • Rongjun Chen Professor of Biomaterials Engineering, Imperial College London

Synopsis

  • Discovering the variation in API ‘encapsulation’ forms and how the drug substance may be associated with the polymer
  • Foreshadowing the potential degradative outcomes to the API over time if over-exposed throughout drug delivery and the impact this has on potency of drug
  • Categorising your API based on potential to degrade and structuring the polymer accordingly to provide a protective property

1:45 pm Lunch & Networking

Maximizing Polymeric Drug Delivery Across a Range of Disease Indications, Reducing Toxic Outcomes

2:45 pm Panel Discussion: Exploring the Toxicity and Immunogenicity of Polymers in Comparison to Other Delivery Vehicles Available to Industry

  • Rongjun Chen Professor of Biomaterials Engineering, Imperial College London
  • Maria Varghese Scientist, Delivery Chemistry, Tiba Biotech
  • Branden Ryu Founder & Chief Executive Officer, Biorchestra
  • Sinead Sunner Senior Analytical Scientist, Blueberry Therapeutics

Synopsis

  • Debating the potential negative side effects associated with polymeric toxicity despite the tailored delivery benefits developed, proving challenging to push through to clinical trails
  • Researching the potential for overcoming polymer-related immune responses that exhibit less potent immunogenicity
  • Assessing whether complete immunosuppression is a realistic challenge to overcome in polymer delivery vehicles and therefore posing the potential to reduce immune responses enough whilst maximizing delivery

3:30 pm Treating Brain Disorders with Dextrin-Based Polymers

Synopsis

  • β-cyclodextrin and other natural dextrin are exploited as starting materials for the synthesis of polymers with excellent properties as delivery systems of several active molecules
  • The dextrin-based polymers can be tailored to encapsulate drugs, oligonucleotides, and antibodies via well-established synthetic protocols
  • The possible therapeutic applications are broad, including the local brain delivery of siRNA and chemotherapeutic drugs for glioblastoma, and the oral delivery of dopamine receptor agonists for neurodegenerative diseases

4:00 pm RNABL: A Polyester Dendrimer-Based Platform for Therapeutic RNA delivery

Synopsis

  • RNABL dendrimers are a class of molecularly defined highly branched biodegradable molecules with lower reactogenicity and better safety characteristics
  • RNABL nanoparticles displayed improved characteristics compared to other non-viral nucleic acid delivery platforms
  • Structural modifications of RNABL delivery materials resulted in organ specific nucleic acid delivery (e.g. lungs, spleen)

4:30 pm Outlining the Mechanisms of Nanoparticle Delivery to Solid Tumours

Synopsis

  • Interrogating the underlying mechanisms of how polymeric nanoparticles enter and exit solid tumours to overcome barriers that impede their delivery
  • Reviewing the Active Transport and Retention (ATR) principle for the delivery of polymeric nanoparticles to solid tumours
  • Guiding the next generation of rational design for developing cancer nanomedicine

5:00 pm Chair’s Closing Remarks

5:15 pm End of Day One