Conference Day Two

9:00 am Check-in & Morning Coffee

9:15 am Chair’s Opening Remarks

Triggering Pinpoint Targeting of the Drug Substance Through Innovative Delivery Techniques

9:30 am C-suite Fireside Chat – Reviewing the Polymeric Drug Delivery Landscape for 2024


An exclusive opportunity to hear from the C-Suite thought leaders at the forefront of polymeric innovations across the biotech landscape. An insightful discussion reviewing the latest developments in the space and an eye to what the future holds across this stimulating field of science.

10:15 am Relaying the Chemical Data from Polymer Synthesis to Create a Targeted Delivery Vehicle


  • Understanding the impact targeting moieties as well as overall polymer design can have on the delivery of the drug substance
  • Modifying the size and length of the polymer to prove suitable for the environment of the route and target cell to maximize efficiency
  • Developing stimuli sensitive polymers to allow conditions such as pH and temperature to control drug release

10:45 am Leveraging Polymer Conjugate Chemistry to Optimize the Delivery of Small Molecules


  • Spotlighting the attachment and release of API to the polymer to ensure optimal pharmacokinetic profiles
  • Showing how enzymatic release of the API can affect efficacy and alleviate undesired side effects
  • Understanding how the Polymer Conjugate is absorbed, distributed and excreted from the body

11:15 am Brain Target Delivery of RNA Therapeutics using the Polymeric Micelle

  • Branden Ryu Founder & Chief Executive Officer, Biorchestra


  • Biorchestra Drug Delivery System (BDDSTM) is a proprietary technology utilizing nonlipid polymer ion complex and brain targeting technology. Design and synthesis of target and non-target polymers will be discussed.
  • BDDSTM technology is compatible with multiple RNA species with various length (e.g., ASO, siRNA & mRNA). Application of RNA encapsulating BDDSTM in animal models of several neurodegenerative diseases will be introduced.
  • Future of BDDSTM as a therapeutic option for CNS diseases carrying large payloads including CRISPR Cas 9, guide RNA, and DNA will be discussed.

11:45 am Morning Refreshments & Networking

Seeking Alignment in Characterization of Polymers to Form a Thorough Analytical Profile

12:15 pm Panel Discussion: Rationalizing the CQAs of Polymer Delivery Vehicles to Promote Batch to Batch Consistency, Reducing Regulatory Scrutiny


  • Distinguishing the current critical quality attributes industry and academia are utilising to assess the potency of the drug product
  • Determining how important the size of the polymeric molecule could prove to be in the delivery of the API
  • Comparing drug products to understand CQAs which remain a constant for regulators and areas which creates variability

1:00 pm Reflecting the Functional Impact of Poly Dispersity Index for Drug Delivery Across a Sample


  • Spotlighting the variance which can be witnessed in PDI across polyermic drug delivery vehicles and how this impacts functionality
  • Reducing accumulation risk with consistent physicochemical properties which are proven as safe, outlining techniques to create homogenous monodisperse samples
  • Advancing technology available to quanitfy PDI to gain definitive data surrounding the origin of heterogeneity across a sample

1:30 pm Overcoming Challenges Associated with Polymer Quantification to Ensure Safe and Efficient API Delivery

  • Sinead Sunner Senior Analytical Scientist, Blueberry Therapeutics


  • Nanoparticle formulations create unique challenges in analytical methods as the presence of the nanoparticles themselves can impact on the methods used
  • Outlining that phase selection is key to chromatographing polymers with weak chromophores
  • Discussing the process of developing and optimising assays for complex polymer formulations

2:00 pm Lunch & Networking

Spearheading the Next-Generation of Formulation Technology to Exploit the Polymer Potential

3:00 pm Analyzing the Array of Polymer Formulations Available to Industry with an Appreciation of Peak Application


  • Classifying the array of polymeric drug delivery systems with an assessment of alternative formulative techniques
  • Promoting transferable learnings between formulation approaches to establish core principals which remain across polymer chemistry and formulation
  • Driving innovation with an eye to the future in the next-generation of polymeric formulations to maximize efficiency and safety

3:30 pm Developing Formulative Methods Appropriate to Protect Polymer and API from Damage


  • Examining the encapsulative capacity of the polymer with a review on the protection of API to forsee degredative imapcts of drug substance
  • Modifying the degree of shear force required to formulate in accordance to the durability of API and polymer design
  • Adapting the human input for formulation around the self assembly properties of the polymer whilst creating a versatile vehicle

4:00 pm Polymeric nanoparticle-mediated in situ co-delivery of RNAi and chemotherapy drugs for cancer immunotherapy

  • Yuang Chen Postdoctoral Associate, Massachusetts Institute of Technology


  • Introducing a polymeric nanoparticle system that is highly effective in tumor targeting through effective tumor EC-mediated active targeting while minimizing LSEC-mediated liver uptake
  • Outlining the effectiveness of controlling tumor growth using this dual treatment strategy that can simultaneously co-deliver chemotherapy drugs with novel immunotherapies
  • Spotlighting the translational effect of targeting Xkr8 in combination with chemotherapy for the treatment of various types of cancers in clinic

4:45 pm Chair’s Closing Remarks

5:00 pm End of Conference